Select Safety Information: Don't use estrogens if you have unusual vaginal bleeding, have or had cancer, stroke, heart attack, liver problems, bleeding disorders, or are pregnant. Do not take these products if you are allergic to any of the ingredients or you think you may be pregnant.
In general, for Premarin, Premarin Vaginal Cream, and Estring, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus. Progestins should not be taken with Duavee.
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with and without progestins may increase your chances of cancer, strokes, blood clots, heart attacks, and dementia. Estrogens should be used at the lowest dose possible for only as long as needed.
Call your doctor if you get new breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden severe headaches, severe chest or leg pain, or swollen lips, tongue and face, memory loss or confusion. Please see full Important Safety Information on website.